TJ – have you found many tires that were really out of bed? I could see being concerned with a rear tire that was 0.5-1.0″ different in circumference than the other side. But I haven’t come across to much of a difference to warrant a concern.
Bob – I do know guys that buy lots of tires and match them up by size. But I don’t know anyone who staggers them. But if you did want to, you could put larger diameter tire on the outside rear wheel.