With a clone on MG Yellows, maybe you would encounter too much grip.
But you need to adapt your chassis to the grip level of the tires. Of course the handling will change with new tires. You probably don’t want full caster on brand new MG Yellows for example. Taking some “grip” out of the chassis by removing caster, narrowing front track, widening rear track, removing front torsion bars etc. will help counteract that massive grip increase you get from new tires and will make the kart much more usable.